We find ourselves with a food system that is not only deeply environmentally unsustainable but also hugely wasteful when taken as a whole. Agriculture is entering a new era marked by scarce resources, a changing environment, changing consumer expectations, greater demand, and potentially higher price and supply volatility. It is projected that to keep up with the growth in human population, more food will have to be produced worldwide over the next 50 years than has been during the past 10,000 years combined all on a substrate of natural resources that are already under stress. A new set of challenges are now being placed on our industrialized food system that it is ill-equipped to deal with. A paradigm shift is needed in how we organize food systems and deliver nutrition in a world of 8 billion-plus people.